Biking Against Death

May 27, 2007

Naptime!

Filed under: hd, neurogenesis — deathbiker @ 12:40 am

I need some naptime whenever I bike more than about twenty minutes,
preferably almost as long a nap as I spend riding. This is yet
another problem to face when spending much time each day biking. How
does Lance do it?

Not only do I feel tired after riding for a while without napping, but
in effect, the neurons are much more available after the nap.
E.g., I feel smarter, but only after the nap.

May 24, 2007

Neurogenesis Adaptability, in Research and For Me

Filed under: hd, neurogenesis — deathbiker @ 2:02 am

Sorry I haven’t been blogging so much.

There’s an interesting online Scientific American article.
It’s about neurogenesis adaptability research at Johns Hopkins.

. . . The team found that there is a two-week window, or critical
period, about a month after these new cells hatch during which they
act like the neurons of a newborn baby.

That’s pretty hopeful, though it does suggest that there’s also a
month-long pipeline for a neurogenesis program to reach its peak.
That could explain some of my starting troubles. It also explains
something else I feel.

Weirdly, although I clearly am far worse at plenty of skills than I
was before I developed my disease, the daily neurogenesis gives
my thinking a kind of immediate and adaptable feel that I used to have
only when I was a kid, and later, when I biked to class in college.
But that feeling is deceptive, since I clearly can’t do as much now.

It confuses other people, because I look more awake and aware
than most people, and even can be more energetic strictly at doing
simple things or things I do alot. People come to wrong conclusions
about my abilities or get confused trying to judge me.

I also have a comment about something else in the article:

“Unfortunately, adult neurogenesis is limited to very specific
structures of the brain and, therefore, the remainder of the brain is
left with reduced levels of plasticity typical of ‘old’ cells.”

This is true. You old cells will stay, more or less, and become more
and more swiss-cheese-like, especially for us HD patients. But
Properties of computer neural net simulations give me some hope that
that can avoid being too limiting. Neural nets are intrinsically very
adaptable to additions and subtractions. BUT, using long-term
neurogenesis deliberately to reverse HD and other neurodegenerative
diseases is utterly new; it’s only been done unwittingly, at most. We
don’t know how it will work out.

You do, I think, have to make sure and regularly practice skills that
you want back or want to have instead. I regularly practice my
pre-disease skills, though not as much as I would wish.

There is some evidence I see that long-term neurogenesis can be
successful. I have a hobby of reading biographies, especially
Presidential ones. Virtually every President has, at least exercised
more than usual at some point. All the ones in my lifetime have had
daily serious routines. The current one even shares my habit of
biking more or less first thing each day. For all we always like to
grumble about stupidity of Presidents in office, he did get there
somehow.

And I’ve seen a case or two of HD patients that exercise alot having
very slow onsets.

May 11, 2007

Goop Update

Filed under: hydration, neurogenesis — deathbiker @ 10:42 pm

In my hydrating goop post, I theorized that:

  • The goop would be lots more effective with some meat in it for protein.
  • The goop would also make a good marinade. Both ideas worked out.I put a little ham in, and it does work clearly better for recovery
    now despite the samllish amounts. A cat suggested I should try some
    tunafish as well, since it should last well also.

    Oh, and yes, it makes a good marinade, too. First I tried it with
    some cheap steak, but though it DID marinate well, the flavor wasn’t
    so great (IMHO, too sweet for steak). But I just put it into ground
    beef that went into enchilada filling, and that, I thought, came out
    well. I suspect it might also work well for meatballs.

  • May 8, 2007

    Bad Days

    Filed under: hd, neurogenesis — deathbiker @ 12:39 am

    On these days, I think back to a line in one of LeGuin’s Earthsea books:
    “On these days, all things done are ill-done.” Because it’s true. On
    bad days, I’m likely to mess up anything I try. I’m likely to
    hurt myself biking or doing repairs. Cooking is likely to fall on the
    floor at some point (I lost TWO lasagna attempts this way). Blogposts
    will be hopelessly messed up.

    I have them about every two weeksish, but am not entirely sure, because
    I haven’t been able to get myself to log them (yeah, I tried to do it
    the day AFTER, but still no joy). Alot of the time, they come the
    day after hard physical work or drinking, but not always.

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